Análise de biomarcadores em ar exalado como ferramenta para rastreio diagnóstico precoce de doenças

Abstract

This undergraduate thesis presents a bibliographic review on the subject of biomarkers analysis determined in exhaled air by patients, with the intention of diagnosing diseases early. Heart failure is a disease with high mortality and it is relevant to emphasize that these patients have a specific odor. Thus, studies that seek new strategies for this disease’s diagnosis become promising. Therefore, based on this distinctive smell characteristic in these patients, a viable alternative is the analysis of exhaled air. This analysis is a non-invasive technique already used in other diseases’ diagnosis. However, for this evaluation to be successful, it is necessary to use a biomarker that detects this specific disease. An alternative, in the case of heart failure diagnosis, is acetone, which can also identify patients with diabetes. Thus, the objective of this study is to find methods and techniques that can be used in order to detect heart failure (HF) using the acetone biomarker.