Análise dos desfechos das gestações em mulheres com lúpus eritematoso sistêmico a longo prazo no Hospital de Clínicas da Universidade Federal de Uberlândia

Abstract

Systemic lupus erythematosus predominantly affects women of reproductive age, making pregnancy a high-risk period. Although obstetric outcomes have been extensively studied, data on late post-pregnancy clinical outcomes remain limited, particularly in Brazilian cohorts. To describe maternal and fetal outcomes, disease activity, post-pregnancy flares, cumulative organ damage, and therapeutic management in women with SLE during the late post-pregnancy period. A longitudinal retrospective cohort study including 27 women with SLE followed at a tertiary rheumatology outpatient clinic who experienced pregnancies between 2017 and 2023. A high frequency of prematurity, lifetime abortion history, and post-pregnancy flares was observed, despite low rates of fetal and neonatal death. Most patients had low disease activity at the time of evaluation according to the SLEDAI, and 55.6% achieved remission status based on the DORIS criteria. Corticosteroid use was associated with post-pregnancy flares, whereas hydroxychloroquine and azathioprine were not associated with adverse maternal or neonatal outcomes. These findings highlight the importance of long-term and individualized follow-up after pregnancy to optimize disease control in women with SLE.