Avaliação prognóstica da hemogasometria venosa em cães com edema pulmonar agudo, secundário à degeneração mixomatosa valvar mitral

Abstract

Venous blood gas analysis is a test widely used in the evaluation of acid-base disorders and may have prognostic value in cardiorespiratory diseases. The objective of this study was to determine the prognostic utility of blood gas parameters in predicting outcome (death or discharge) in dogs with acute pulmonary edema secondary to myxomatous mitral valve degeneration. A retrospective study was carried out with 42 dogs diagnosed with cardiogenic pulmonary edema, divided into two groups: survivors (n=27) and nonsurvivors (n=15). pH, PvCO2, HCO3 -, base excess (BE) and lactate were analyzed. The Student's t test and the Wilcoxon test were applied to compare groups, and the effect size was measured by Cohen's d and order biserial correlation. The parameters HCO3 - (p=0.015; d=0.803) and BE (p=0.017; r=0.434) were significantly lower in the death group, indicating a relationship between metabolic acidosis and worse prognosis. pH (p=0.099; d=0.523), PvCO2 (p=0.223; d=0.383) and lactate (p=0.173; r=0.276) were not significant predictors of mortality. The results suggest that metabolic acidosis at diagnosis, assessed by HCO3 - and BE, may be a negative prognostic factor in dogs with cardiogenic pulmonary edema. Additional studies with a larger sample and multivariate analysis are recommended to confirm these findings.