Efeito do diamino fluoreto de prata na dentira irradiada: análise de composição química

Abstract

Patients undergoing radiotherapy in the head and neck region experience adverse effects, including cavities related to ionizing radiation, representing a significant challenge for professionals in terms of managing these injuries. The objective of this study was to evaluate the effect of Silver Diamino Fluoride (DFP) on the chemical characteristics of irradiated human dentin in vivo. To achieve this objective, twelve healthy third molars and twelve premolars and molars were collected from post-head and neck radiotherapy patients. The teeth were categorized into two groups (n=12). In both groups, 38% Silver Diamino Fluoride (SDF, SDI Limited, Victoria, Australia) was applied. Dentin analysis was carried out in two phases: before applying DFP and after 1 month. Hemisections were subjected to Fourier transform infrared spectroscopy (FTIR) before and after DFP application. Data were analyzed using two-way ANOVA, followed by Tukey's post hoc test. FTIR analysis revealed differences attributed to irradiation in the Carbonate component (p = 0.047) and to DFP in the Amide I band (p= 0.006), Carbonate (p = 0.008) and in all ratios: C:F (P=0.004), M:M (P=0.005) and AmideI:AmideIII (P=0.007). The application of DFP to irradiated dentin led to structural changes in the organic portion, reorganization of more soluble minerals and formation/deposition of minerals.