Análise de espaços sinusoidais e fibrose em fígados de ratos com periodontite apical crônica associada à inalação passiva de fumaça de cigarro e consumo crônico de álcool

Abstract

This study aimed to assess the impact of chronic alcohol consumption and passive tobacco smoke inhalation, alone or combined, on hepatic health in rats with apical periodontitis (AP), compared to rats without AP. Thirty-five female adult Wistar rats were divided into five groups: control (no AP, no alcohol or smoke exposure), control-AP (induced AP only), ShS-AP (AP with passive smoke exposure), A-AP (AP with alcohol consumption), and A+ShS-AP (AP with both alcohol and passive smoke exposure). Liver samples were histologically analyzed for fibrosis and sinusoidal space quantification. While AP and deleterious habits did not induce significant fibrosis, the control group exhibited smaller sinusoidal spaces compared to all other groups (p < 0.05). Induced AP groups showed similar sinusoidal dilation percentages (p > 0.05). Overall, AP combined with alcohol consumption and passive smoke inhalation could significantly increase sinusoidal spaces in rats’ liver. However, there’s no effect in hepatic fibrosis.