Análise da expressão do gene da proteína HP1 e do elemento de transposição Het-A na linhagem 6175 de Drosophila melanogaster em resposta à exposição crônica ao herbicida glifosato

Abstract

The high demand for food and the increasing use of herbicides, such as glyphosate, raise concerns about sustainability and potential environmental and public health impacts. Brazil, as the world's largest consumer of glyphosate-based herbicides, faces challenges related to the selection of weed species resistant to these herbicides and emerging indications of adverse effects on humans, necessitating continuous toxicological monitoring to establish new safety limits. This study aimed to investigate the effects of the herbicide Roundup Original® on the expression of genes related to telomere maintenance and the position effect variegation (PEV) phenotype in Drosophila melanogaster flies. The results demonstrate differentiation compared to the negative control in both eye pigment analysis and the expression of Su(var)2-5 genes and the Het-A transposition element. These findings suggest possible glyphosate-induced gene expression regulation and imply that higher concentrations of glyphosate may lead to the death of affected cells.