1. Repositório Institucional - Universidade Federal de Uberlândia
2. Faculdade de Odontologia (FOUFU)
3. TCC - Odontologia

ORCID:	http://orcid.org/0000-0001-7865-2795
Document type:	Trabalho de Conclusão de Curso
Access type:	Acesso Embargado
Title:	Efeitos de diferentes materiais à base de silicato de cálcio na resistência à fratura de dentes permanentes imaturos com reabsorção radicular por substituição e na osteoclatogênese: um estudo laboratorial
Author:	Freitas, Gabrielle Alves Nunes
First Advisor:	Moura, Camilla Christian Gomes
First coorientator:	Souza, Gabriela Leite de
First member of the Committee:	Soares, Priscilla Barbosa Ferreira
Second member of the Committee:	Soares, Carlos José
Third member of the Committee:	Peres, Thiago Silva
Summary:	Objective(s): This study evaluated the effects of Biodentine (BD), Bio-C repair (BCR), and mineral trioxide aggregate plug (MTA) on fracture resistance of simulated immature teeth with replacement root resorption (RRR) and in vitro induced osteoclastogenesis. Materials and Methods: Sixty bovine incisors simulating immature teeth and RRR were divided into five groups: BD and BCR, completely filled with respective materials; MTA, a 3-mm apical plug of MTA; RRR, no root canal filling (negative control); PL, no RRR, and root canal filling performed (positive control). All the teeth underwent mechanical fatigue, and then compression strength testing was performed using an Instron universal testing machine. RAW 264.7 macrophages were treated with 1:16 extracts of BD, BCR, and MTA containing receptor activator of nuclear factor-kappa B ligand (RANKL) for 5 days. RANKL-induced osteoclast differentiation was assessed by staining with tartrate-resistant acid phosphatase. Fracture load and osteoclast number were analyzed using one-way analysis of variance (ANOVA) and Tukey’s test (α=0.05). Results: No significant difference in fracture resistance was observed among the groups (P>0.05). All materials similarly inhibited osteoclastogenesis (P>0.05), except for BCR, which showed a lower percentage of osteoclasts than MTA (P<0.0001). The presence of RRR did not affect the fracture strength of the simulated immature teeth and the materials tested did not significantly strengthen them. Conclusion(s): The treatment options used to treat non-vital immature teeth with RRR do not strengthen them and provide similar resistance to fractures. BD, MTA, and BCR showed inhibitory effects on osteoclast differentiation, with BCR group showing better results.
Keywords:	Fracture strength Non-vital tooth Osteoclastogenesis Root resorption Silicate cement
Area (s) of CNPq:	CNPQ::CIENCIAS DA SAUDE
Language:	eng
Country:	Brasil
Publisher:	Universidade Federal de Uberlândia
Quote:	FREITAS, Gabrielle Alves Nunes. Efeitos de diferentes materiais à base de silicato de cálcio na resistência à fratura de dentes permanentes imaturos com reabsorção radicular por substituição e na osteoclatogênese: um estudo laboratorial. 2022. 26 f. Trabalho de Conclusão de Curso (Graduação em Odontologia) – Universidade Federal de Uberlândia, Uberlândia, 2023.
URI:	https://repositorio.ufu.br/handle/123456789/36700
Date of defense:	5-Dec-2022
Appears in Collections:	TCC - Odontologia

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