Fabricação e caracterização de fantomas de tecido para estudo e aplicação da técnica de imagem no domínio de frequência espacia (SFDI)

Abstract

The Spatial Frequency Domain Imaging (SFDI) technique is a non-invasive way of diagnosing skin lesions by determining the optical properties of tissue. The method is capable of quantifying the reduced scattering coefficient and absorption coefficient, using diffuse reflection maps generated in images of epithelial tissue. As a way of studying and developing this technique, the present work aimed at the assembly and characterization of tissue-mimicking materials, the so-called phantoms, which are used in the calibration and validation of new diagnostic techniques. For the application of the SFDI through the equipment set up in the Laboratório de Imagens Funcionais (LimF) of the Universidade Federal de Uberlândia (UFU), nine phantoms were constructed that simulate human skin, with the addition of an absorber material (India Ink) and a scattering component (Titanium Dioxide), over a polydimethylsiloxane (PDMS) matrix. Another equipment also used for the optical characterization of the phantoms was the integrating sphere, which was used as a comparison method for the results obtained through the SFDI, which proved to be efficient in the optical characterization of the phantoms by the absorption coefficient maps that had a variation between 0 to 0.3 mm-1 and reduced scattering coefficient which assumed values from 0 to 2.5 mm-1.