Síntese e caracterização de complexos de cobre(II) contendo hidrazidas alifáticas e 1,10 - fenantrolina

Abstract

The present work describes the preparation of new Cu(II) complexes containing aliphatic hydrazides and 1,10 – phenanthroline for further evaluation of the antitumor potential of the synthesized molecules. The ternary complexes of the type [Cu(N–O)(N–N)(NO3)2], where N–O = octanohydrazide (octh), decanohydrazide (dech), dodecanohydrazide (dodh) and N–N = 1,10 – phenanthroline were synthesized in a 1:1:1 ratio using the trihydrated copper(II) nitrate salt as precursor. The compounds obtained were characterized by elemental and conductimetric analysis, as well as by UV – Vis spectroscopy (solid state and in solution), infrared (IR) and mass spectrometry. CHN analyzes are in agreement with the proposed structures and infer that the complexes have a high degree of purity. The molar conductivity values indicate that in solution the complexes are 2:1 electrolytes in accordance with the proposed structures. In solution, bands in the UV – Vis region referring to intraligand transitions appeared displaced in relation to the free ligands, indicating metallic coordination. Additionally, a d–d band attributed to the CuII ion was observed in the solid state and in solution in the region between 600 and 800 nm. The infrared spectra corroborate that the hydrazides are coordinated in a bidentate fashion to the metallic center and that the nitrate ion participates in the coordination sphere of the complex. The mass spectra of the compounds contribute to the structural proposal of the synthesized molecules. The antitumor potential of the complexes proposed in this work will be further evaluated and reported in future publications.