Efeitos da sinvastatina em lesões ósseas criadas experimentalmente na tíbia de ratos Wistar

Abstract

Simvastatin is a drug of the statins group which has as its main function the inhibition of the activity of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA), reducing the synthesis of cholesterol in the liver. These drugs are widely used to reduce cholesterol, but it has been observed that statins act in the remodeling and formation of bone tissue, being an osteoinductive substance. A total of 45 Wistar rats were submitted to surgical scaling on the proximal third in both tibias, using a 2.0 mm diameter surgical steel drill. After the operation, the animals were divided into two groups treated orally via gavage, the first group (GI) received only the diluent and the second group (GII), simvastatin. The groups were divided into three subgroups of 05 animals each, each analyzed at 03, 07 and 14 postoperative days. At the end of the respective days of observation and treatment, the animals were submitted to euthanasia with a dose of thiopental. After this procedure, the animals had their tibias collected through their proximal and distal disarticulation, the right tibiae being destined to the histological analysis and the left ones, to the biomechanical test.