1. Repositório Institucional - Universidade Federal de Uberlândia
2. Instituto de Biotecnologia (IBTEC)
3. TCC - Biotecnologia (Uberlândia)

Document type:	Trabalho de Conclusão de Curso
Access type:	Acesso Aberto
Title:	Virtual screening of potential inhibitors against N-myristoyltransferase from Plasmodium vivax
Author:	Lima, Germano Yoneda Pereira
First Advisor:	Nicolau Junior, Nilson
First member of the Committee:	Silva, Luiz Borges Bispo da
Second member of the Committee:	Miguel, Tarciso Tadeu
Summary:	Malaria is a tropical disease caused by parasites from Plasmodium vivax, which are normally associated with Anopheles spp. In 2016, an estimated 216 million cases occurred worldwide, causing 445 000 deaths. N-myristoyltransferase (NMT) is a very important enzyme related with the transfer of myristate acid from myristoyl coenzyme A to specific proteins in the glycine N-terminal residue, this process occurs at the same time of the translation, for this, aminopeptidases withdraw the initial methionine, making glycine the N-terminal amino acid. NMT inhibition demonstrated to leads parasite to cell death. To predict new potential inhibitors against NMT Plasmodium, Computer-Aided Drug Design (CADD) tools were used to alignment of pharmacophores, virtual screening, validation, docking and molecular dynamics.
Keywords:	Plasmodium N-myristoyltranferase Bioinformatics
Area (s) of CNPq:	CNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA::PROTOZOOLOGIA DE PARASITOS
Language:	eng
Country:	Brasil
Publisher:	Universidade Federal de Uberlândia
Quote:	LIMA, Germano Yoneda Pereira. Virtual Screening of potential inhibitors against N- myristoyltransferase from Plasmodium vivax. 2018. 31 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2018.
URI:	https://repositorio.ufu.br/handle/123456789/24254
Date of defense:	10-Dec-2018
Appears in Collections:	TCC - Biotecnologia (Uberlândia)

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