Publicação: Virtual screening of potential inhibitors against N-myristoyltransferase from Plasmodium vivax
Carregando...
Tipo do documento
Data
Direito de acesso
Coleções
Programa
Área do conhecimento
CNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA::PROTOZOOLOGIA DE PARASITOS
Título da Revista
ISSN da Revista
Título de Volume
Autores
Orientador
Coorientador
Resumo
Malaria is a tropical disease caused by parasites from Plasmodium vivax, which are normally associated with Anopheles spp. In 2016, an estimated 216 million cases occurred worldwide, causing 445 000 deaths. N-myristoyltransferase (NMT) is a very important enzyme related with the transfer of myristate acid from myristoyl coenzyme A to specific proteins in the glycine N-terminal residue, this process occurs at the same time of the translation, for this, aminopeptidases withdraw the initial methionine, making glycine the N-terminal amino acid. NMT inhibition demonstrated to leads parasite to cell death. To predict new potential inhibitors against NMT Plasmodium, Computer-Aided Drug Design (CADD) tools were used to alignment of pharmacophores, virtual screening, validation, docking and molecular dynamics.
Abstract
Palavras-chave
Plasmodium, N-myristoyltranferase, Bioinformatics
Citação
LIMA, Germano Yoneda Pereira. Virtual Screening of potential inhibitors against N- myristoyltransferase from Plasmodium vivax. 2018. 31 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2018.