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  2. Instituto de Biotecnologia (IBTEC)
  3. TCC - Biotecnologia (Uberlândia)
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dc.creatorLima, Germano Yoneda Pereira-
dc.date.accessioned2019-02-11T12:39:20Z-
dc.date.available2019-02-11T12:39:20Z-
dc.date.issued2018-12-10-
dc.identifier.citationLIMA, Germano Yoneda Pereira. Virtual Screening of potential inhibitors against N- myristoyltransferase from Plasmodium vivax. 2018. 31 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2018.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/24254-
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPlasmodiumpt_BR
dc.subjectN-myristoyltranferasept_BR
dc.subjectBioinformaticspt_BR
dc.titleVirtual screening of potential inhibitors against N-myristoyltransferase from Plasmodium vivaxpt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Nicolau Junior, Nilson-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/0821186870496558pt_BR
dc.contributor.referee1Silva, Luiz Borges Bispo da-
dc.contributor.referee2Miguel, Tarciso Tadeu-
dc.creator.Latteshttp://lattes.cnpq.br/4582360094197657pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoMalaria is a tropical disease caused by parasites from Plasmodium vivax, which are normally associated with Anopheles spp. In 2016, an estimated 216 million cases occurred worldwide, causing 445 000 deaths. N-myristoyltransferase (NMT) is a very important enzyme related with the transfer of myristate acid from myristoyl coenzyme A to specific proteins in the glycine N-terminal residue, this process occurs at the same time of the translation, for this, aminopeptidases withdraw the initial methionine, making glycine the N-terminal amino acid. NMT inhibition demonstrated to leads parasite to cell death. To predict new potential inhibitors against NMT Plasmodium, Computer-Aided Drug Design (CADD) tools were used to alignment of pharmacophores, virtual screening, validation, docking and molecular dynamics.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiotecnologiapt_BR
dc.sizeorduration31pt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA::PROTOZOOLOGIA DE PARASITOSpt_BR
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