Please use this identifier to cite or link to this item:
https://repositorio.ufu.br/handle/123456789/24254
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DC Field | Value | Language |
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dc.creator | Lima, Germano Yoneda Pereira | - |
dc.date.accessioned | 2019-02-11T12:39:20Z | - |
dc.date.available | 2019-02-11T12:39:20Z | - |
dc.date.issued | 2018-12-10 | - |
dc.identifier.citation | LIMA, Germano Yoneda Pereira. Virtual Screening of potential inhibitors against N- myristoyltransferase from Plasmodium vivax. 2018. 31 f. Trabalho de Conclusão de Curso (Graduação em Biotecnologia) – Universidade Federal de Uberlândia, Uberlândia, 2018. | pt_BR |
dc.identifier.uri | https://repositorio.ufu.br/handle/123456789/24254 | - |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Uberlândia | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Plasmodium | pt_BR |
dc.subject | N-myristoyltranferase | pt_BR |
dc.subject | Bioinformatics | pt_BR |
dc.title | Virtual screening of potential inhibitors against N-myristoyltransferase from Plasmodium vivax | pt_BR |
dc.type | Trabalho de Conclusão de Curso | pt_BR |
dc.contributor.advisor1 | Nicolau Junior, Nilson | - |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/0821186870496558 | pt_BR |
dc.contributor.referee1 | Silva, Luiz Borges Bispo da | - |
dc.contributor.referee2 | Miguel, Tarciso Tadeu | - |
dc.creator.Lattes | http://lattes.cnpq.br/4582360094197657 | pt_BR |
dc.description.degreename | Trabalho de Conclusão de Curso (Graduação) | pt_BR |
dc.description.resumo | Malaria is a tropical disease caused by parasites from Plasmodium vivax, which are normally associated with Anopheles spp. In 2016, an estimated 216 million cases occurred worldwide, causing 445 000 deaths. N-myristoyltransferase (NMT) is a very important enzyme related with the transfer of myristate acid from myristoyl coenzyme A to specific proteins in the glycine N-terminal residue, this process occurs at the same time of the translation, for this, aminopeptidases withdraw the initial methionine, making glycine the N-terminal amino acid. NMT inhibition demonstrated to leads parasite to cell death. To predict new potential inhibitors against NMT Plasmodium, Computer-Aided Drug Design (CADD) tools were used to alignment of pharmacophores, virtual screening, validation, docking and molecular dynamics. | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.course | Biotecnologia | pt_BR |
dc.sizeorduration | 31 | pt_BR |
dc.subject.cnpq | CNPQ::CIENCIAS BIOLOGICAS::PARASITOLOGIA::PROTOZOOLOGIA DE PARASITOS | pt_BR |
Appears in Collections: | TCC - Biotecnologia (Uberlândia) |
Files in This Item:
File | Description | Size | Format | |
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VirtualScreeningPotential.pdf | TCC | 1.04 MB | Adobe PDF | View/Open |
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