Estudo da participação de receptores NMDA dos gânglios da raiz dorsal em modelo de neuropatia por constrição crônica em ratos

Abstract

Neuropathic pain induced by surgery is a significant clinical problem, and develops due to peripheral nerve injuries during surgical procedures. Studies suggest that after the nerve injury the cell bodies of sensory neurons dorsal root ganglia are a significant source of ectopic discharge. In these structures are the glutamatergic NMDA receptors, which according to research participate in pain of inflammatory origin, and its activation is related to abnormal manifestations of pain. In this study, we of NMDA receptors in the dorsal root ganglia in the development and maintenance of postoperative neuropathic pain. For this, a sensitivity test was performed mechanics for 28 days, in animal model of chronic constriction of sciatic nerve treated with NMDA receptor antagonists via intrathecal and intraganglionic. The results showed an increase in the sensitivity threshold in the groups treated through the two routes, suggesting that the process of chronic pain can be related to events mediated by the NMDA receptor present in the sensory ganglia and the control of pain in the inflammatory phase may prevent the development of chronic postoperative pain.