Resistência antimicrobiana em isolados clínicos de Klebsiella pneumoniae em um hospital na cidade de Uberlândia, Minas Gerais

Abstract

Klebsiella pneumoniae (Enterobacteriaceae) is one of the main microorganisms occurring in hospitals. It is resistant to about 95% of the currently used drugs. The main goal of the present study was to investigate the resistance patterns of clinic samples of Klebsiella pneumoniae at a public hospital in the municipality of Uberlândia, state of Minas Gerais, southeastern Brazil. We analyzed 42 samples of Klebsiella pneumoniae resistant to carbapenemic antibiotics, considering the resistance patterns to other antimicrobials and their classes, as well as classifying them in multiresistant or extensively resistant. Our results showed that most samples had come from outside Intensive Therapy Unities (ITUs), urinary infection, and resistance to fluoroquinolone, penicillanic, cephalosporinic, and monobactamic antibiotics. Moreover, it was observed 4% of resistance to Polymyxin B and most isolates showed to be extensively resistant. Thus, isolated cultures revealed to be resistant to the main antimicrobials, particularly resistant in ITUs and especially in 2014. It is known that many different factors affect the development of microbial resistance and, thus, it is necessary to increase preventive measures by applying the best practices to the common routine of patient assistance, involving increased disinfection of the environment, continued guidance and attention to the process of hand cleaning by health personnel, besides the appropriate control of the antimicrobials to be used.