Potencial anti-leishmania de novos complexos de rutênio (II): efeito na interação parasito-hospedeiro

Abstract

The leishmaniasis are considered by the World Health Organization, a disease neglected by many ways, mainly because of lack of investment in more effective and insurance new therapeutic agents. It is a parasitic disease caused by protozoa of the genus leishmania and can be classified into cutaneous leishmaniasis, leishmaniasis mucocutaneous and visceral leishmaniasis. Current treatment has a number of complications, such as high toxicity, high cost and parasite resistance. In this perspective the development of new safer and less costly therapeutic agents becomes appropriate. Inorganic medicinal chemistry represents a very promising and attractive area in controlling various diseases, through the development of new therapeutic agents based on bioactive metal complexes. Several studies have demonstrated the potential use of metal complexes in different pathologies such as cancer and parasitary diseases. The present study aims to evaluate the anti-Leishmania potential of new ruthenium (II) complexes (1–3) in the promastigote cytotoxicity and their effect on parasite-host interaction against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis e Leishmania (Leishmania) infantum.