Pressão intra-ocular com implante de tubo de teflon associado à mitomicina C em coelhos da raça Nova Zelândia

Abstract

New Zealand kind 14, adult, male and female rabbits were used to evaluate sclera histological aspects, bulbar conjunctiva and clinical after the implant of the teflon tube in the anterior chamber associated with subconjuntival mitomycin C. Ten right-eyes were part of group I and ten left-eyes were part of group II evaluated for 30 and 60 days of post-operatory (PO), respectively. The other eight were part of group III, observed for 48 hours. A bag were formed in the bulbar conjunctiva, and mitomycin C was applied inside it, for three minutes. A teflon tube was introduced in the anterior chamber and fixated in the sclera, the conjunctival bag were aproximated on the limbus over the implant. There was a significative difference when measuring the intraocular pressure (IOP) between the pre-operatory and the post-operatory of 30 and 60 days. The animals on the groups I and II manifested hypotony and plain anterior chamber on the first two PO weeks. In 27 eyes (96,5%), the bag remained with volume and filled with aqueous humor. On the conjunctival bag histological evaluation after 48 PO hours, only the presence of the basal layer and conjunctive tissue degeneration were noticed. In 30 days, the absence of vascularization and secretion cells were noticed, and in 60 days, an atypical scar process were noticed. The teflon tube implant, associated with topical application of subconjunctival mitomycin C, showed itself as a safe and efficient method in normotense rabbits, lowering the IOP and keeping it for 30 to 60 PO days.