Interações farmacológicas no uso de anticonvulsivantes, opioides e antidepressivos em cães e gatos: elaboração de uma cartilha

Abstract

The occurrence of pharmacological interactions in Small Animal Internal Medicine represents an important risk factor for adverse events, therapeutic failures, and increased mortality in hospitalized animals undergoing concomitant use of multiple medications. Drugs that act on the central nervous system have a high potential for pharmacokinetic and pharmacodynamic interactions, directly impacting patient prognosis and requiring constant attention from the veterinarian during therapeutic management. Given the need for accessible and reliable information to support clinical and hospital routines, this study aimed to develop a Pharmacological Interactions Handbook focusing on anticonvulsants, antidepressants, and opioids, which are frequently used in veterinary practice. The tool was developed through an in-depth review of the scientific literature available in high-impact medical and veterinary journals using the PubMed database, employing keywords encompassing drug names and their uses in dogs and cats. Thus, updated information on the mechanisms of drug interactions, possible clinical consequences, and management strategies was compiled, aiming to assist therapeutic decision-making and promote greater safety for canine and feline patients in hospital settings. Therefore, it was concluded that drug interactions in Small Animal Internal Medicine remain a poorly elucidated factor and still require further studies.