Perfil clínico-imunológico e avaliação da atividade de doença em pacientes com Doença de Sjögren: estudo observacional em centro de referência brasileiro

Abstract

Sjögren’s disease (SjD) is a systemic autoimmune condition characterized by chronic inflammation of exocrine glands and heterogeneous extraglandular manifestations. This study aimed to analyze the clinical, laboratory, and histopathological profile of patients with SjD followed at a tertiary referral center, as well as to explore the relationship between immunological markers, histological findings, and standardized indices of disease activity. This retrospective observational study was based on the review of medical records from patients treated at the Hospital de Clínicas of the Federal University of Uberlândia (HC-UFU). Demographic characteristics, diagnostic criteria, minor salivary gland biopsy findings, and validated indices of systemic disease activity and patient-reported symptoms were evaluated. The integrated analysis of these parameters allowed the characterization of disease behavior in the studied cohort and supported a discussion on the relative contribution of different diagnostic tools and assessment instruments in clinical practice. The findings highlight the multifaceted nature of Sjögren’s disease and reinforce the importance of a multidimensional approach for accurate diagnosis and appropriate management in specialized care settings.