1. Repositório Institucional - Universidade Federal de Uberlândia
2. Faculdade de Medicina (FAMED)
3. TCC - Enfermagem

Document type:	Trabalho de Conclusão de Curso
Access type:	Acesso Aberto
Title:	Role of maternal milk in providing a healthy intestinal microbiome for the preterm neonate
Author:	Natal, Ana Catarina de Castro Menezes, Ralciane de Paula Röder, Denise Von Dolinger de Brito
First Advisor:	Röder, Denise Von Dolinger de Brito
First coorientator:	Menezes, Ralciane de Paula
First member of the Committee:	Leal, Geraldo Sadoyama
Second member of the Committee:	Ferreira, Isadora Caixeta da Silveira
Summary:	The immature gastrointestinal tract of preterm neonates leads to a delayed and distinctive establishment of the gut microbiome, making them susceptible to potentially pathogenic bacteria and increasing the risk of infections. Maternal milk, recognized as the optimal source of nutrition, plays a multifaceted role in modulating the gut microbiome of premature newborns. Human milk oligosaccharides, acting as prebiotics, provide essential nourishment for key bacteria such as Bifidobacterium, contributing to the proliferation of beneficial bacterial populations. Additionally, maternal milk is rich in Immunoglobulins that stimulate immune cell responses, providing protective effects on the infant’s gut mucosa. Moreover, bioactive proteins such as secretory immunoglobulin A (SIgA), lactoferrin, lysozyme, and mucins play a crucial role in defending against pathogens and regulating the immune system at the cellular level. These proteins contribute not only to infection prevention but also emphasize the impact of breast milk in fortifying the body’s innate defenses. This multifaceted role of maternal milk, including essential nutrients, beneficial bacteria, and bioactive proteins, highlights the importance of promoting the mother’s own milk feeding in the Neonatal Intensive Care Unit (NICU). It not only optimizes the long-term outcomes and well-being of preterm infants but also provides a holistic approach to their health and development.
Keywords:	Preterm neonate Maternal milk Gut microbiome Infections
Area (s) of CNPq:	CNPQ::CIENCIAS DA SAUDE
Language:	eng
Country:	Brasil
Publisher:	Universidade Federal de Uberlândia
Quote:	NATAL, Ana Catarina de Castro; MENEZES, Ralciane de Paula; RÖDER, Denise Von Dolinger de Brito. Role of maternal milk in providing a healthy intestinal microbiome for the preterm neonate. Pediatric Research, v. 97, n. 6, p. 2235–2242, 2025. DOI https://doi.org/10.1038/s41390-024-03751-x
URI:	https://repositorio.ufu.br/handle/123456789/48154
Date of defense:	11-Dec-2024
Appears in Collections:	TCC - Enfermagem

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