SDMA como indicador precoce de lesão renal aguda em cadelas com piometra

Abstract

Acute kidney injury (AKI) is characterized by the sudden and persistent loss of kidney function, with infectious conditions, such as pyometra, being one of the main causes. The evaluation of kidney function involves the use of biomarkers such as creatinine, SDMA, and urea, which play a key role in detecting renal changes. Urine specific gravity (USG) and the urine protein-creatinine ratio (UPC) are also essential tools for evaluating kidney function and injury. Compared to creatinine, SDMA reflects the glomerular filtration rate (GFR) more accurately, being less influenced by non-renal factors. This study aims to evaluate the early detection of two methodologies for measuring SDMA, comparing them with creatinine levels in female dogs diagnosed with pyometra and correlating the results with renal histopathological findings. The goal is to identify the effectiveness of these methodologies in detecting AKI and their relationship with variations in biomarker levels based on the degree of AKI as determined by renal histopathology. The study also aims to assess the diagnostic accuracy of SDMA in identifying AKI, using renal histopathology as the gold standard for diagnosis, and to compare the precision and accuracy of two commercial methods for measuring SDMA: Catalyst One IDEXX and ELISA SDMA (Bioassay Technology Laboratory).