Associação entre o ácido úrico sérico e parâmetros bioquímicos.

Abstract

Background: serum uric acid (UA) levels have been associated with several biochemical parameters, including markers analyzed in the lipidogram, glomerular filtration rate (GFR), creatinine and urea. However, there is no consensus in the literature on the association of UA with these indicators. Objective: associate biochemical parameters with serum UA levels. Methods: a cross-sectional study including 1,029 individuals was conducted using data from NHANES (2011-2012). Weight and height were assessed by the Lohman protocol. UA and urea were analyzed by enzymatic methods. Creatinine was measured by the Roche/Hitachi Modular P analyzer and estimated glomerular filtration rate by the Chronic Kidney Disease Epidemiology Collaboration equation. Glucose was measured by glucose oxidase method, and total cholesterol (TC) and HDL-c by timed endpoint. Low density lipoprotein (LDL) was calculated by Friedewald. Regression analyses were performed to evaluate the association of serum UA levels with biochemical parameters, considering significance when p < 0.05. Results: serum UA levels were positively associated with TC (β = 4.374; p = 0.011), triglycerides (β = 10.852; p = 0.010), LDL (β = 3.252; p = 0.023), urea (β = 0.510; p = 0.033) and creatinine (β = 0.045; p = <0.001). And inversely with GFR (β = -3.639; p = <0.001). Conclusion: serum UA levels were positively associated with LDL, triglycerides, TC, creatinine and urea, and inversely with GFR.