Associação entre o ácido úrico sérico e parâmetros de adiposidade corporal

Abstract

Introduction: Hyperuricemia is characterized by elevated serum uric acid (UA) levels. Increased UA levels have been associated with body adiposity parameters, including obesity. However, it is not fully clarified in the literature whether body adiposity, evaluated by the different fat compartments, is associated with serum UA levels. Objective: To associate UA levels with body adiposity parameters. Methods: This is a cross-sectional study conducted with 1,029 individuals, both men and women, over the age of 20. Body composition was assessed using densitometry, weight and height measurements according to the Lohman protocol, circumferences were measured with a tape measure, and UA levels were determined by an enzymatic method. The comparison between normal and elevated serum UA levels was carried out using linear regression analysis. All regression analyses were performed both unadjusted and adjusted for confounding variables. Results: A positive association was observed between serum UA levels and the following body adiposity parameters: BMI, waist circumference, fat mass, subcutaneous fat, visceral fat, abdominal fat, and gynoid and android fat. Conclusion: The results indicate a positive association between serum UA levels and body adiposity parameters. These findings are in line with the literature, which points to a significant relationship between elevated UA and body adiposity in individuals with obesity.