Potencial estimulador da combinação de PRF e osso bovino desproteinizado no reparo ósseo em pacientes com câncer de cabeça e pescoço: um estudo clínico controlado e randomizado

Abstract

Head and neck cancer significantly impacts the quality of life of patients. Among treatment options, radiotherapy is highly effective but also damages surrounding healthy tissues. This study aimed to assess the benefits of applying platelet-rich fibrin (PRF) combined with deproteinized bovine bone (Sticky Bone) for bone formation after tooth extraction in radiotherapy patients. Fifteen patients were selected and randomized regarding the sockets to receive either a blood clot (control) or Sticky Bone (experimental). Six patients completed all follow-ups and were evaluated during 60 days post-oncological treatment. Clinical follow-ups were conducted to assess the surgical site, and bone repair was analyzed using qualitative radiographic assessments by three blinded examiners. Data were analyzed using the Mann-Whitney test, multilevel binary regression, and mixed-effects regression to explore the association between interventions and outcomes (α = 0.05). Regardless of the evaluation period, PRF use did not significantly influence outcomes. However, there was a notable improvement in evaluation scores at 7 days post-surgery compared to subsequent assessments. Sticky Bone shows potential to enhance osteoradionecrosis treatment; however, no significant impact on tissue and bone regeneration was observed within 60 days of radiotherapy.