Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.ufu.br/handle/123456789/37220
ORCID:  http://orcid.org/0000-0003-2196-7029
Tipo de documento: Tese
Tipo de acceso: Acesso Embargado
Fecha de embargo: 2025-02-13
Título: Epigenética do desenvolvimento inicial em bovinos e as técnicas de reprodução assistida
Título (s) alternativo (s): Early development epigenetics in cattle and the assisted reproduction techniques
Autor: Vargas, Luna Nascimento
Primer orientador: Franco, Maurício Machaim
Primer miembro de la banca: Goulart, Vivian Alonso
Segundo miembro de la banca: Bonetti, Ana Maria
Tercer miembro de la banca: Fonseca, Marcio José Poças
Cuarto miembro de la banca: Soares, Anelise dos Santos Mendonça
Resumen: Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During the early mammalian development, two global waves of epigenetic reprogramming occur. The first one occurs during the prenatal phase of gametogenesis and the second one begins immediately after fertilization. Environmental factors such as exposure to chemicals, nutrition, behavioral factors, stress, in vitro culture conditions, can influence the epigenetic reprogramming during early development. In this review, we describe the main epigenetic marks and the epigenetic events such as the genomic imprinting and X chromosome inactivation that occur during the early mammalian developmet. Moreover, we discuss the detrimental effects of cloning procedure on the establishment of the epigenetic patterns and some molecular alternatives to minimize these negative impacts.
Abstract: Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During the early mammalian development, two global waves of epigenetic reprogramming occur. The first one occurs during the prenatal phase of gametogenesis and the second one begins immediately after fertilization. Environmental factors such as exposure to chemicals, nutrition, behavioral factors, stress, in vitro culture conditions, can influence the epigenetic reprogramming during early development. In this review, we describe the main epigenetic marks and the epigenetic events such as the genomic imprinting and X chromosome inactivation that occur during the early mammalian developmet. Moreover, we discuss the detrimental effects of cloning procedure on the establishment of the epigenetic patterns and some molecular alternatives to minimize these negative impacts.
Palabras clave: Epigenetics
Early embryo development
Somatic cell nuclear transfer
Reprogramming
Methylome
DMRs
Cattle
X-chromosome inactivation
Gene Expression
Embryogenesis
Histone
Sperm
Fertility
Biomarker
Cloning
Single-cell
Genética
Área (s) del CNPq: CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA ANIMAL
Tema: Genética
Bovinos - Melhoramento genético
Epigenética
Gado - Reprodução
Idioma: eng
País: Brasil
Editora: Universidade Federal de Uberlândia
Programa: Programa de Pós-graduação em Genética e Bioquímica
Cita: VARGAS, Luna Nascimento. Epigenética do desenvolvimento inicial em bovinos e as técnicas de reprodução assistida. 2023. 164 f. Tese (Doutorado em Genética) - Universidade Federal de Uberlândia, Uberlândia, 2023. DOI http://doi.org/10.14393/ufu.te.2022.619
Identificador del documento: http://doi.org/10.14393/ufu.te.2022.619
URI: https://repositorio.ufu.br/handle/123456789/37220
Fecha de defensa: 3-feb-2023
Aparece en las colecciones:TESE - Genética e Bioquímica

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