Please use this identifier to cite or link to this item:
https://repositorio.ufu.br/handle/123456789/37220
ORCID: | http://orcid.org/0000-0003-2196-7029 |
Document type: | Tese |
Access type: | Acesso Embargado |
Embargo Date: | 2025-02-13 |
Title: | Epigenética do desenvolvimento inicial em bovinos e as técnicas de reprodução assistida |
Alternate title (s): | Early development epigenetics in cattle and the assisted reproduction techniques |
Author: | Vargas, Luna Nascimento |
First Advisor: | Franco, Maurício Machaim |
First member of the Committee: | Goulart, Vivian Alonso |
Second member of the Committee: | Bonetti, Ana Maria |
Third member of the Committee: | Fonseca, Marcio José Poças |
Fourth member of the Committee: | Soares, Anelise dos Santos Mendonça |
Summary: | Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During the early mammalian development, two global waves of epigenetic reprogramming occur. The first one occurs during the prenatal phase of gametogenesis and the second one begins immediately after fertilization. Environmental factors such as exposure to chemicals, nutrition, behavioral factors, stress, in vitro culture conditions, can influence the epigenetic reprogramming during early development. In this review, we describe the main epigenetic marks and the epigenetic events such as the genomic imprinting and X chromosome inactivation that occur during the early mammalian developmet. Moreover, we discuss the detrimental effects of cloning procedure on the establishment of the epigenetic patterns and some molecular alternatives to minimize these negative impacts. |
Abstract: | Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During the early mammalian development, two global waves of epigenetic reprogramming occur. The first one occurs during the prenatal phase of gametogenesis and the second one begins immediately after fertilization. Environmental factors such as exposure to chemicals, nutrition, behavioral factors, stress, in vitro culture conditions, can influence the epigenetic reprogramming during early development. In this review, we describe the main epigenetic marks and the epigenetic events such as the genomic imprinting and X chromosome inactivation that occur during the early mammalian developmet. Moreover, we discuss the detrimental effects of cloning procedure on the establishment of the epigenetic patterns and some molecular alternatives to minimize these negative impacts. |
Keywords: | Epigenetics Early embryo development Somatic cell nuclear transfer Reprogramming Methylome DMRs Cattle X-chromosome inactivation Gene Expression Embryogenesis Histone Sperm Fertility Biomarker Cloning Single-cell Genética |
Area (s) of CNPq: | CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA ANIMAL |
Subject: | Genética Bovinos - Melhoramento genético Epigenética Gado - Reprodução |
Language: | eng |
Country: | Brasil |
Publisher: | Universidade Federal de Uberlândia |
Program: | Programa de Pós-graduação em Genética e Bioquímica |
Quote: | VARGAS, Luna Nascimento. Epigenética do desenvolvimento inicial em bovinos e as técnicas de reprodução assistida. 2023. 164 f. Tese (Doutorado em Genética) - Universidade Federal de Uberlândia, Uberlândia, 2023. DOI http://doi.org/10.14393/ufu.te.2022.619 |
Document identifier: | http://doi.org/10.14393/ufu.te.2022.619 |
URI: | https://repositorio.ufu.br/handle/123456789/37220 |
Date of defense: | 3-Feb-2023 |
Appears in Collections: | TESE - Genética e Bioquímica |
Files in This Item:
File | Description | Size | Format | |
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EpigenéticaDesenvolvimentoInicial.pdf Until 2025-02-13 | Tese | 3.7 MB | Adobe PDF | View/Open Request a copy |
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