Please use this identifier to cite or link to this item: https://repositorio.ufu.br/handle/123456789/37220
ORCID:  http://orcid.org/0000-0003-2196-7029
Document type: Tese
Access type: Acesso Embargado
Embargo Date: 2025-02-13
Title: Epigenética do desenvolvimento inicial em bovinos e as técnicas de reprodução assistida
Alternate title (s): Early development epigenetics in cattle and the assisted reproduction techniques
Author: Vargas, Luna Nascimento
First Advisor: Franco, Maurício Machaim
First member of the Committee: Goulart, Vivian Alonso
Second member of the Committee: Bonetti, Ana Maria
Third member of the Committee: Fonseca, Marcio José Poças
Fourth member of the Committee: Soares, Anelise dos Santos Mendonça
Summary: Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During the early mammalian development, two global waves of epigenetic reprogramming occur. The first one occurs during the prenatal phase of gametogenesis and the second one begins immediately after fertilization. Environmental factors such as exposure to chemicals, nutrition, behavioral factors, stress, in vitro culture conditions, can influence the epigenetic reprogramming during early development. In this review, we describe the main epigenetic marks and the epigenetic events such as the genomic imprinting and X chromosome inactivation that occur during the early mammalian developmet. Moreover, we discuss the detrimental effects of cloning procedure on the establishment of the epigenetic patterns and some molecular alternatives to minimize these negative impacts.
Abstract: Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary sequence of DNA. The main epigenetic mechanisms are DNA methylation, post-translational covalent modifications in histone tails, and non-coding RNAs. During the early mammalian development, two global waves of epigenetic reprogramming occur. The first one occurs during the prenatal phase of gametogenesis and the second one begins immediately after fertilization. Environmental factors such as exposure to chemicals, nutrition, behavioral factors, stress, in vitro culture conditions, can influence the epigenetic reprogramming during early development. In this review, we describe the main epigenetic marks and the epigenetic events such as the genomic imprinting and X chromosome inactivation that occur during the early mammalian developmet. Moreover, we discuss the detrimental effects of cloning procedure on the establishment of the epigenetic patterns and some molecular alternatives to minimize these negative impacts.
Keywords: Epigenetics
Early embryo development
Somatic cell nuclear transfer
Reprogramming
Methylome
DMRs
Cattle
X-chromosome inactivation
Gene Expression
Embryogenesis
Histone
Sperm
Fertility
Biomarker
Cloning
Single-cell
Genética
Area (s) of CNPq: CNPQ::CIENCIAS BIOLOGICAS::GENETICA::GENETICA ANIMAL
Subject: Genética
Bovinos - Melhoramento genético
Epigenética
Gado - Reprodução
Language: eng
Country: Brasil
Publisher: Universidade Federal de Uberlândia
Program: Programa de Pós-graduação em Genética e Bioquímica
Quote: VARGAS, Luna Nascimento. Epigenética do desenvolvimento inicial em bovinos e as técnicas de reprodução assistida. 2023. 164 f. Tese (Doutorado em Genética) - Universidade Federal de Uberlândia, Uberlândia, 2023. DOI http://doi.org/10.14393/ufu.te.2022.619
Document identifier: http://doi.org/10.14393/ufu.te.2022.619
URI: https://repositorio.ufu.br/handle/123456789/37220
Date of defense: 3-Feb-2023
Appears in Collections:TESE - Genética e Bioquímica

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