Avaliação hematológica e histopatológica de neoplasia de oviduto em jararaca-do-norte Bothrops atrox de cativeiro

Abstract

The Bothrops atrox species is of great interest in commercial breeding in captivity, with the objective of research and development of realizations of realizations of the properties of this venom. Pharmaceutical use brings with it the great responsibility of maintaining health, safety and quality standards from the breeding of animals to the final purification of this product. Veterinary medicine comes with studies of reptiles with common practice, and with this comes patterns in blood parameters for animals, and thus having a basis for identifying major health change, even before the appearance of symptoms. Among the forms of complementary evaluation in veterinary medicine, the hemogram provides important information on the general health status of the patient, is quick to perform and has a low cost. In addition, it is noted in captive females, the occurrence of neoplais in the oviduct region, which compromises the quality of life. Thus, the objective of this research was to define well the reference for blood count of healthy snakes of the species Bothrops atrox, males and females, as well as to study how possible changes in these parameters in females with neoplasia in the region of the oviducts. Blood samples were collected from 20 healthy specimens of B. atrox, males and females, and from ten specimens identified with neoplasia in the oviducts, all housed in the commercial breeding facility Pentapharm do Brasil. The mean values and standard deviations found for healthy B.atrox were: hematocrit 33.6 ± 5.47%, hemoglobin 10.81 ± 2.07g/dL, total number of erythrocytes 0.59 ± 0.1 x 106/mm3, leukocytes 11387.5 ± 3279.2/mm3 and thrombocytes 28175 ± 6320/mm3. No significant difference was observed between males and females and heterophils were the predominant leukocyte cell type. In Bothrops atrox with benign neoplasm, lymphopenia and thrombocytopenia were observed, and eosinophils were not visualized. The same changes were also observed in the two snakes that received the histopathological diagnosis of fibrosarcoma, in addition to presenting anemia.