Síntese e avaliação citotóxica de complexos de cobre (II) contendo ligantes n-doadores

Abstract

The present work describes the preparation of new Cu(II) complexes containing N-donor ligands and their respective cytotoxic activities against normal and tumor cells of lung and prostate. The ternary complexes of the type [Cu(N–N)(N–N)(NO3)2], where N-N = 2-(2-pyridyl)benzimidazole (pbz), 2,2′-dipyridylamine (dpa), 1, 10 – phenanthroline (phen), 2,2'-bipyridine (bipy), 4-methylphenylterpyridine (4-mf-terpy), 4-4′-dimethoxy-2-2′-bipyridine (dmt), were synthesized in proportion 1:1:1 using the trihydrated copper(II) nitrate salt as a precursor. The compounds obtained were characterized by elemental and conductimetric analysis, as well as by UV-Vis (solid and solution state) and infrared (IR) spectroscopy. CHN analyzes are in agreement with the proposed structures and infer that the complexes have a high degree of purity. The molar conductivity values indicate that in solution the complexes are 2:1 electrolytes in accordance with the proposed structures. In solution, bands in the UV-Vis region referring to intraligand transitions appeared displaced in relation to the free ligands, indicating metal coordination. Additionally, for each complex prepared, a d–d band attributed to the Cu(II) ion was observed in the solid state and in solution in the region between 600 and 800 nm, corroborating the proposed structures.