Avaliação biomecânica da osseointegração de implantes com superfície sta em ratos tratados com bifosfonatos

Abstract

This study evaluated the osseointegration of implants with triply activated surface (STA) in animals submitted to administration of bisphosphonates through biomechanical analysis. Sixty-four rats were randomly alocated into 4 groups (n=16): MAQ/CTR – Machined implants installed in control animals; STA/CTR – STA implants installed in control animals; MAQ/BIF – Machined implants installed in animals challenged with bisphosphonates; STA/BIF – STA implants installed in animals challenged with bisphosphonates. Treatments with sodium alendronate (1mg/kg/week) or saline solution began for one month prior to implant placement by a weekly subcutaneous administration. Then, the animals were submitted to implant placement in the tibias and euthanized in the periods of 15 and 45 days after the surgical procedure. Biomechanical analysis was performed to evaluate the removal torque of implant. An increase in implant removal torque was observed within 45 days compared to 15 days (p<0.05) in both groups (p<0.05). In addition, in CTR animals, a greater removal torque of STA implants compared to MAQ implants was noted at 15 days (p<0.001). MAQ implants installed in BIF animals showed higher removal torque forces compared to the same type of implants installed in CTR animals within 15 days (p<0.05). It can be concluded that the use of STA implants contributes to an increase in the removal torque in CTR animals compared to MAQ implants.