Uso da membrana de colágeno não desnaturado na cicatrização de feridas cutâneas induzidas experimentalmente em ratos wistar

Abstract

High incidence of skin wounds in animals in conjunction with the importance of an unimpaired skin in the maintenance of body homeostasis lead to constant search for skin treatment materials. Therefore, the purpose of this study is to evaluate the effects of undenatured collagen membrane in healing of experimental induced skin wounds in Wistar rats. After the resection of a skin fragment, the animals were divided in three groups: control, treated with ultrapure water and treated with undenatured collagen membrane. Fifteen days after surgery, the animals were submitted to euthanasia and the lesion region was collected for histological analysis. Results showed that the group treated with UC-II membrane obtained an accelerated tissue repair compared to the other groups, showing a quick reepithelization and decrease of lymphoplasmacytic infiltrate, as well as presence of cicatricial tissue at day 10 of the treatment. Through these data, it was possible to acknowledge the efficacy of UC-II membrane in skin wound treatment.