Mesotelioma peritoneal epitelioide com metástase pulmonar em felino

Abstract

A feline, female, mixed breed, with two years of age and history of abdominal distension was referred to the Veterinary Hospital of the Federal University of Uberlândia for necropsy. During necropsy, multiple nodules of 0.2 to 2 cm in diameter were observed, coalescent, firm, white, with irregular surface in omentum, serosa of the stomach and large intestine, diaphragm and peritoneum. Similar millimetric nodules were seen, diffusely distributed in the lung parenchyma. The samples of the omitted nodules were submitted to histopathology and immunohistochemistry. The antibodies used were anti-vimentin, anti-cytokeratin AE1 / AE3 and anti-calretinin. Histologically, the nodules observed in the abdominal cavity and pulmonary parenchyma consisted of neoplastic proliferation of mesothelial cells in a solid arrangement. In immunohistochemical analyzes, neoplastic cells showed cytoplasmic immunostaining for cytokeratin AE1 / AE3 and calretinin, and did not exhibit immunoreactivity for vimentin. Based on the anatomopathological and immunohistochemical findings, the diagnosis of epithelioid peritoneal mesothelioma with pulmonary metastasis was attributed.