Síntese e caracterização de complexos de Zinco(II) com Tiossemicarbazonas com potencial biológico

Abstract

Thiosemicarbazones are compounds known as Schiff bases which present chemical versatility in addition to several biological and pharmacological applications. Preliminary biological studies of Zinc(II) complexes with thiosemicarbazones revealed a great biological potential for such compounds. Based on this, the focus of this work was the expansion of the series of zinc complexes based on structural variations in binders TSCs in order to prepare novel Zn(II) complexes, besides evaluating the structure/activity of the complexes. The complexes were characterized by several techniques (absorption spectroscopy in the infrared and UV-Visible regions, magnetic resonance spectroscopy, elemental analysis, nuclear magnetic resonance, fluorescence and molar conductivity), which revealed the occurrence of the reaction 1:2 (metal:binder), consistent with obtaining the following products: [Zn(atc)2] (1) (Hatc = 2-acetylpyridine-thiosemicarbazone), [Zn(atc-Me)2] (2) (Hatc-Me = 2-acetylpyridine- N(4)-methyl- thiosemicarbazone), [Zn(atc-Et)2] (3) (Hatc-Et = 2-acetylpyridine-N(4)- ethyl- thiosemicarbazone), [Zn(atc-Ch)2] (4) (Hatc-Ch = 2-acetylpyridine-N(4)- cyclohexyl- thiosemicarbazone) e [Zn(atc-Ph)2] (5) (Hatc-Ph = 2-acetylpyridine-N(4)- phenyl- thiosemicarbazone). Based on these analyzes, the ligands are coordinated in tridentate form and monoanionic mode resulting in neutral octahedral complexes.