Adenocarcinoma apócrino misto com múltiplas metástase em cão

Abstract

Mixed apocrine adenocarcinoma is an uncommon malignant neoplasm in dogs, with metastatic potential generally for lymph nodes and lungs. This study aimed to report a case of apocrine adenocarcinoma of the mixed type with multiple metastases, in an adult mixed breed dog. The animal was seen at the veterinary hospital - UFU with prostration, anorexia and hind limb paresis, with indication of pulmonary metastasis on chest radiography. Euthanasia was requested and the animal was sent to the animal pathology department at UFU for necropsy, where nodules were observed in the subcutaneous area of the axillary region, head, lung, liver, omentum and brain. Macroscopically, these nodules were firm, with a whitish cut surface and central necrosis region, measuring between 0.2 and 5.0 cm in diameter. Samples of the affected organs were collected during necropsy to perform histopathology and immunohistochemistry to detect estrogen receptors. The macroscopic characteristics, the negative immunohistochemistry in all samples for estrogen receptors, which rules out the main differential diagnosis of breast carcinoma, and mainly the morphological characteristics of the cells, made it possible to arrive at the diagnosis of mixed apocrine adenocarcinoma with multiple metástases. As far as we know, this is the first report of cerebral metastasis of mixed apocrine adenocarcinoma in a dog.