Efeitos da Silimarina (Silybum marianum), alcachofra (Cynara scolymus), mel, aminoácidos com levulose e aminoácidos com proteolisados de fígado na hepatotoxicidade aguda induzida por tetracloreto de carbono em camundongos

Abstract

The liver is a key organ in the metabolism and in the secretory and excretory functions of the body of mammalians, with hepatic desorders being numerous and varied. In light of the controversy regarding the efficacy of the drugs that protect the liver and the intense use of these products in the veterinaiy clinic for the treatment of pre-installed hepatopathy, this experiment aimed to verify the effects in areas with hepatic necrosis of aminoacids such as levulose (Omitargin®), aminoacids with liver proteolysates (Acrosin®), honey and silymarin (Silybum marianum) and artichoke (Cynara scolymus) extracts in the acute hepatotoxicity induced by carbon tetrachloride in mice. In order to verify such effects, Swiss mice were intoxicated with carbon tetrachloride and treated with these substances. The treatments were evaluated at 24, 48 and 72 hours after intoxication through the serie dosage of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), as well as the quantification of the hepatic necrosis. Honey and aminoacids with levulose, and aminoacids with liver proteolysates were inefficient in the treatment of acute toxic hepatopathy. On the other hand, silymarin and artichoke were efficient in the improvement of the serie leveis of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the first 48 hours after an intoxication, though after 72 hours, they presented leveis similar to the other treatments and to the non-treated, intoxicated group. All the treatments tested were inefficient regarding the reduetion of the area with hepatic necrosis.