Estudo da atividade farmacológica anti-inflamatória do extrato aquoso de Campomanesia xanthocarpa em modelo experimental in vivo

Abstract

Campomanesia xanthocarpa is a fruit found in the Brazilian Cerrado, known as guabirobeira, guavirova, guabiroba-miúda and guabirobeira-do-mato, and used in popular medicine to treat inflammatory processes. Phytochemical analyzes have shown that the leaves of this species contain flavonoids, tannins, saponins and essential oil. Flavonoids present scientifically proven anti- inflammatory and immunomodulatory actions. In view of the above, this work plan is based on the use of an in vivo experimental model to evaluate the anti-inflammatory pharmacological properties of the aqueous extract of the leaves of the C. xanthocarpa plant. In order to evaluate the pharmacological anti-inflammatory effects of this species, the leaves were first collected from this species and the aqueous extract prepared. Subsequently, was performed a (i) standardization of the strategy of use of foot edema was performed; (ii) the time required for paw edema analysis after intraplantar administration of carrageenan; (iii) standardization of histological sections for histopathological analysis. The data obtained showed that the aqueous extract of C. xanthocarpa did not present antiedematogenic activity in the model of paw edema induced by carrageenan in BALB/c mice.