Avaliação dos efeitos do citalopram sobre a crise epiléptica induzida no modelo parabss1 de Drosophila melanogaster

Abstract

Epilepsy is currently the fourfth mostly occurring neurologic disease in the world that affects all ages. In humans, its characterized by recurrent seizures crises in a briefly period of time. The dysfunction is also associated with depression cases and it’s treatment can be affected by some antidepressive drugs by a possible neuropsychopharmacologic interaction. Citalopram was choosen in this study as representative antidepressant drug to be evaluated its interaction on the seizure recovery ratio of parabss1 Drosophila melanogaster model organism. The parabss1 model represents a human-like epileptic crise after induced by a mechanical shock. Seizure induction and toxicity experiments was done to show the effects of citalopram on the bang-sensitive fruit flies. According to toxicity results, the drug didn’t manifested any significant toxicity (P<0.05) in any dose tested in comparison to control group. The acute and chronic seizure induction tests after citalopram treatment in 4 different doses revealed, in general, a significantly reduction (P<0.05) on the seizure ratio of fruit flies.