Use este identificador para citar ou linkar para este item: https://repositorio.ufu.br/handle/123456789/21663
Tipo do documento: Trabalho de Conclusão de Curso
Tipo de acesso: Acesso Aberto
Término do embargo: 2020-05-21
Título: Efeitos da radiação ionizante na microarquitetura óssea cortical: alterações específicas relacionadas ao longo do tempo
Título(s) alternativo(s): Effects of ionizing radiation on cortical bone microarchitecture: specific related alterations over time
Autor(es): Borges, Juliana Simeão
Rabelo, Gustavo Davi
Iriê, Milena Suemi
Spin-Neto, Rubens
Paz, João Lucas Carvalho
Primeiro orientador: Soares, Priscilla Barbosa Ferreira
Segundo membro da banca: Soares, Carlos José
Terceiro membro da banca: Carvalho, Luciana Arantes Porto
Quarto membro da banca: Iriê, Milena Suemi
Resumo: This study aimed to evaluate the cortical bone microarchitecture in rabbit tibias at intervals 7, 14 and 21 days after ionizing irradiation. Twelve adult male New Zealand rabbits were treated with a single radiation dose of 30Gy. The animals were randomly divided into 4 groups: Control (no radiation), Ir7, Ir14 and Ir21 days. Computadorized microtomography was used to analyze the microarchitecture of the cortical bone. The following parameters were used: cortical thickness (CtTh), bone volume (BV), total porosity (Ct.Po), intracortical porosity (CtPo (cl)), fractal dimension (FD) and degree of anisotropy (Ct.DA). One-way analysis of variance (ANOVA) was performed for all data followed by Tukey and Dunnet tests. The cortical thickness was different (p <0.01) between the control and irradiated groups, with thicker cortex to Ir 7 days. There was no difference between groups for total porosity, however, intracortical porosity revealed significance difference (p <0.001) between the irradiated groups and the control group, with a lower value for Ir7 days. The number of bone channels, fractal dimension and degree of anisotropy did not show significant difference between groups. The bone volume was lower in the Ir14 group in relation to control. In this way, the microarchitecture of the cortical bone can be affected by radiotherapy and the effects appear to be time-dependent. Cortical parameters found in the group Ir21 days were similar to the control group, suggesting that the cortical bone return to the regular conformation after 21 days.
Notas: Possui versão em CD
Palavras-chave: Radiotherapy
Cortical bone
Microarchitecture
Computadorized
Microtomography
Área(s) do CNPq: CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::RADIOLOGIA ODONTOLOGICA
Idioma: eng
País: Brasil
Editora: Universidade Federal de Uberlândia
Referência: Borges JS, Rabelo GD, Iriê MS, Spin-Neto R, Paz JLC, Soares PBF. Effects of ionizing radiation on cortical bone microarchitecture: specific related alterations over time. 2018. 24 f. Trabalho de Conclusão de Curso (Graduação em Odontologia)- Universidade Federal de Uberlândia, Uberlândia, 2018.
URI: https://repositorio.ufu.br/handle/123456789/21663
Data de defesa: 22-Mai-2018
Aparece nas coleções:TCC - Odontologia

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