Publicação: Efeitos da radiação ionizante na microarquitetura óssea cortical: alterações específicas relacionadas ao longo do tempo
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CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA::RADIOLOGIA ODONTOLOGICA
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This study aimed to evaluate the cortical bone microarchitecture in rabbit tibias at intervals 7, 14 and 21 days after ionizing irradiation. Twelve adult male New Zealand rabbits were treated with a single radiation dose of 30Gy. The animals were randomly divided into 4 groups: Control (no radiation), Ir7, Ir14 and Ir21 days. Computadorized microtomography was used to analyze the microarchitecture of the cortical bone. The following parameters were used: cortical thickness (CtTh), bone volume (BV), total porosity (Ct.Po), intracortical porosity (CtPo (cl)), fractal dimension (FD) and degree of anisotropy (Ct.DA). One-way analysis of variance (ANOVA) was performed for all data followed by Tukey and Dunnet tests. The cortical thickness was different (p <0.01) between the control and irradiated groups, with thicker cortex to Ir 7 days. There was no difference between groups for total porosity, however, intracortical porosity revealed significance difference (p <0.001) between the irradiated groups and the control group, with a lower value for Ir7 days. The number of bone channels, fractal dimension and degree of anisotropy did not show significant difference between groups. The bone volume was lower in the Ir14 group in relation to control. In this way, the microarchitecture of the cortical bone can be affected by radiotherapy and the effects appear to be time-dependent. Cortical parameters found in the group Ir21 days were similar to the control group, suggesting that the cortical bone return to the regular conformation after 21 days.
Abstract
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Radiotherapy, Cortical bone, Microarchitecture, Computadorized, Microtomography
Citação
Borges JS, Rabelo GD, Iriê MS, Spin-Neto R, Paz JLC, Soares PBF. Effects of ionizing radiation on cortical bone microarchitecture: specific related alterations over time. 2018. 24 f. Trabalho de Conclusão de Curso (Graduação em Odontologia)- Universidade Federal de Uberlândia, Uberlândia, 2018.