Efeito antitumoral in vitro de complexos de cobre(II) em células tumorais de colo de útero

Abstract

The cervical cancer is frequent on feminine population. Estimative appoints in 2017, incidence of 7,9% of new cervical cancer in women in Brazil. Researchers for the development of new antitumor property medicines is relevant as long as the conventional treatments show outrageous side effects. Therefore, the metal complexes are getting relevant as alternative and promising cancer therapy. On this work, were evaluated three complexes of copper(II) and quinaldic acid and associated to ligands phenanthroline (C7), bipyridine (C8) and quinaldic acid (C9) and their isolated ligands in cervical cancer cell lineages and human umbilical vein endothelial cells. It was analyzed complexes’ and ligands’ cytotoxic capacity and the complexes which presented better cellular toxicity were tested with cellular antiproliferation, death mechanism and tumor lineage adhesion assays. The C9 complex didn’t show any significative cytotoxicity effects. The complexes C7 and C8 showed significant toxicity only to tumor cells and for anti-proliferation cell essay, both were capable to stop proliferation on that kind of cell. The complex C7 showed capacity to activate the cell apoptosis and inactivate the cellular attachment on cancer cell line. The chemical compounds isolated did not showed any relevant cytotoxic activities.