Caracterização do diacetato de celulose modificado como um material alternativo para dispositivo de liberação medicamentosa em periodontia

Abstract

Although mechanical therapy promotes satisfactory results on periodontal disease control, the completely remotion of periodontal biofilm within the periodontal pocket with medium and high depth is rare. Thus, the use of local antimicrobials, like tetracycline (TET), has been proposed as an adjunct to periodontal therapy. The aim of this study was to evaluate the modified cellulose diacetate (MCD) as a tetracycline carrier in Local Delivery Device (DLL). Therefore, commercial cellulose diacetate (CCD) was modified and incorporated with TET. The material was characterized and posteriorly the devices were immersed in 25ml of phosphate buffer solution, remaining in thermostatic bath at 36,5 °C during 105 days. The solutions were analyzed in the spectrophotometer at 265nm and 355nm wavelength, where the material degradation levels and drug release were verified respectively. Estructural analysis was performed by Scanning Electron Microscopy (MEV). Then calibration curves were created for TET in phosphate buffer solution. The release device fits into a kinetic model of pseudo-second order, allowing calculation of relevant parameters, such as the complete liberation time that was of 168h with a faster release time in the first 24h, than exponentially reduces to zero when it reaches 168h. The system can be characterized as a controlled release device, due to their effective retention even after a long time of the start of the experiment. So, it is viable tool as DLL, when used as coadjutant on periodontal pathogen control and to modulate the inflammatory response on patient.