Níveis de nitrito na saliva e no fluido peri-implantar em humanos

Abstract

Nitric oxide has an important effect on host response. However its potential as a possible diagnostic tool in peri-implant disease has been little studied. In this study the nitrite levels in saliva and peri-implant sulcular fluid (PISF) of partially edentulous patients and the possible correlation between these levels and clinical parameters were determined. Twenty four patients were examined to determine the peri-implant status (healthy or diseased) based on probing depth (PD), bleeding on probing (BOP) and presence of visible plaque (VP). Saliva and sulcular fluid (SF) around teeth (internal control) and dental implants were collected and the nitrite levels were evaluated by the Griess method. Nitrite levels in saliva and SF of these patients were compared and their correlations with clinical parameters were evaluated. Clinical data (BOP and VP) were higher in implants than in matching control teeth, but did not show significance (p>0.05) with the exception of PD. Differences in total nitrite levels in saliva and SF of healthy and diseased groups were not observed (p>0.05). Teeth and implants of healthy or diseased groups did not demonstrate statistical difference regarding nitrite levels (p>0.05). Correlation between clinical parameters and nitrite levels in saliva or SF was not observed in healthy or diseased groups except for VP in implants of the healthy group (p=0.031, r=- 0.72). These results demonstrated similarity between dental sites and implants. The present findings do not allow the use of nitrite as a diagnostic tool for periimplant disease, in patients with slight inflammation.