Análise do perfil de citocinas no fluido de lavado nasal de crianças com rinite alérgica e alterações clínicas após tratamento com mometasona, montelucaste ou desloratadina

Abstract

Allergic rhinitis (AR) represents a global health problem and its prevalence has increased in the last years. The aim of this study is to evaluate the cytokine profile in nasal lavage fluid and the clinical alterations in children with AR after different drugs treatment. This is a prospective randomized open study; twenty-eight children aged from six to twelve years with moderate persistent AR were selected and randomly distributed in three groups of treatment during four weeks with nasal corticosteroid (mometasone), anti-leukotriene (montelukaste), and antihistamine (desloratadine). A daily symptoms score card was filled and the parent s perception of improving was verified. Samples of nasal lavage fluid, before and after treatment, was collected for measuring IL-5, IFN-&#947;, IL-10 e TGF-&#946; by immunoassay (ELISA). There are no differences in symptoms by daily score cards, although all parents referred good or excellent improvement of symptoms perception, with significant difference favorable to mometasone group (p<0.05). Only the group treated with mometasone showed a reduction in IL-5 levels. There are no differences in the levels of IFN-&#947; and TGF-&#946;, while IL-10 levels were above the detection limits. It can be concluded that the group treated with mometasone showed improvement of clinical symptoms as well as reduction in IL-5 levels in the nasal lavage fluid of children with allergic rhinitis.