O uso da suplementação de cetoanálogos e cafeína para o estudo do metabolismo de aminoácidos no exercício em modelos de experimentação humana e animal

Abstract

Ammonia (described in this study as a synonym for NH3 + NH4+) is toxic and promotes deleterious effects on the central nervous system of human and murine. The ammonia metabolism and increase the concentration of ammonia in tissues can be studied by physical exercises. The temporary disturbances in the central nervous system caused by exercise are similar to those observed in liver disease and neurodegenerative disorders. Thus, the high-intensity exercise has been implicated in the development of fatigue and exhaustion due to increased plasma ammonia concentrations. The use of ketoanalogues and/or caffeine supplementation decreases the concentration of ammonia in the blood during exercise to promote better performance. Thus, ketoanalogues and/or caffeine supplementation combined with exercise can delay or overcome the toxic effect of high ammonia. This study investigated the protective effect of ketoanalogues and caffeine supplementation against nitrogen compounds, and the physical performance in humans and rats subjected to physical exercise of high intensity and short duration.