Manifestações orais de doenças imunomediadas: evidências clínicas e epidemiológicas de um serviço de referência regional

Abstract

This study addresses immune-mediated diseases with oral manifestations, a heterogeneous group of conditions that significantly impact patients' quality of life and pose diagnostic challenges due to overlapping clinical features among different diseases. The research was conducted at a regional referral center, the Dental Hospital of the Federal University of Uberlândia, and comprised two complementary investigations. The first consisted of a retrospective observational analysis of the clinical, demographic, and therapeutic characteristics of patients diagnosed with oral lichen planus. The second explored the coexistence of psoriasis and oral pemphigus vulgaris, discussing potential underlying immunopathological mechanisms. Together, these studies highlight the importance of clinicopathological correlation, multidisciplinary management, and longitudinal follow-up in the care of patients with oral immune-mediated diseases, contributing to the improvement of diagnostic and therapeutic strategies within the Brazilian Unified Health System.