Farmacoterapia das hiperlipidemias endócrinas: conceitos e atualidades

Abstract

Hyperlipidemia, defined as elevated circulating lipid levels, is a common condition in dogs and may occur as either a primary disorder—often breed-related, such as in Miniature Schnnauzer—or as a secondary manifestation of underlying diseases. Secondary forms are more frequently associated with endocrine and metabolic disorders, including diabetes mellitus, hypothyroidism, hyperadrenocorticism, obesity, pancreatitis, and cholestasis. These lipid abnormalities, which include hypercholesterolemia and hypertriglyceridemia, can lead to significant complications such as pancreatitis, hepatic dysfunction, biliary disease, ocular alterations, and neurological signs. Given their clinical relevance, this study aims to explore the pharmacological approaches used to manage these conditions, focusing on the physiological mechanisms involved and current therapeutic advances in veterinary medicine.