1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Instituto de Ciências Biomédicas (ICBIM)
  3. TCC - Ciências Biomédicas
Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.ufu.br/handle/123456789/46210
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dc.creatorSandim, Bruna Coelho-
dc.date.accessioned2025-06-25T12:38:32Z-
dc.date.available2025-06-25T12:38:32Z-
dc.date.issued2025-04-25-
dc.identifier.citationSANDIM, Bruna Coelho. Complexo metálico de Pd(II) como uma abordagem terapêutica inovadora contra o vírus Mayaro. 2025. 20 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2025.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/46210-
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo a Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Embargadopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAntiviralpt_BR
dc.subjectMayaro viruspt_BR
dc.subjectMetallic complexespt_BR
dc.titleComplexo metálico de Pd(II) como uma abordagem terapêutica inovadora contra o vírus Mayaropt_BR
dc.title.alternativePd(II) metal complex as an innovative therapeutic approach against Mayaro viruspt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor-co1Cassani, Natasha Marques-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/7568339804522929pt_BR
dc.contributor.advisor1Jardim, Ana Carolina Gomes-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7960921685798643pt_BR
dc.contributor.referee1Mesquita, Nathalya Cristina de Moraes Roso-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/4643554485061867pt_BR
dc.contributor.referee2Sanches, Paulo Ricardo da Silva-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/8425845140191642pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/9961632622469139pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoMayaro virus (MAYV) is the etiological agent of Mayaro fever, a disease characterized by chills, fever, dizziness, gastrointestinal manifestations, headache, ocular pain, myalgia, and arthralgia. Additionally, the infection can progress to a chronic condition in over 50% of patients, characterized by severe and prolonged arthralgia. Nonetheless, there are no specific antiviral drugs or vaccines available against MAYV infection, being the clinical management based on controlling symptoms. In that regard, metal complexes emerge as an approach in drug development due to their therapeutic potential against different viruses. In this study, we evaluated the in vitro antiviral activity of the ligand N-[[4-(phenylmethoxy)phenyl]methyl]-2-pyridinemethanamine (L) and its complexes with palladium (Pd), platinum (Pt), and zinc (Zn) against MAYV. In that regard, Vero E6 cells were infected with MAYV expressing a nanoluciferase reporter (MAYV-nanoluc) and simultaneously treated with the complexes at concentrations ranging from 2.34 to 300 M for 24 h, when virus replication was measured by quantifying nanoluciferase activity. Dichloro-N-[[4-(phenylmethoxy)phenyl]methyl]-2-pyridinemethanamine-Pd(II) [L-Pd(II)] presented the highest SI and was selected for further assays. This complex showed promising activity in inhibiting early stages of MAYV infection, such as entry into the host cells and virucidal effect, suggesting that it may interact with the virus particle. Additionally, L-Pd(II) displayed significant activity on the post-entry stages of the replicative cycle. The data presented here indicates the potential of this complex as a promising candidate for the development of future antiviral drugs against MAYV.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.sizeorduration20pt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIApt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.embargo.termsIII - resultados de pesquisa cujo conteúdo seja passível de ser patenteado ou publicado em livros e capítulospt_BR
dc.orcid.putcode186712083-
dc.description.embargo2027-06-25-
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