1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Faculdade de Odontologia (FOUFU)
  3. TCC - Odontologia
Please use this identifier to cite or link to this item: https://repositorio.ufu.br/handle/123456789/45316
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dc.creatorBites, Clara de Oliveira Barbosa-
dc.date.accessioned2025-04-29T12:29:03Z-
dc.date.available2025-04-29T12:29:03Z-
dc.date.issued2025-03-31-
dc.identifier.citationBITES, Clara de Oliveira Barbosa. Investigating Microarchitectural Characteristics of Woven Bone Exposed to Ionizing Radiation: Comparative Analysis of Two Segmentation Methods and Their Impact on Trabecular Measurements in an Animal Study. 2025. 18 f. Trabalho de Conclusão de Curso (Graduação em Odontologia) – Universidade Federal de Uberlândia, Uberlândia, 2025.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/45316-
dc.description.sponsorshipFAPEMIG - Fundação de Amparo a Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Abertopt_BR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectBonept_BR
dc.subjectFractalspt_BR
dc.subjectX-Ray Microtomographypt_BR
dc.titleInvestigating Microarchitectural Characteristics of Woven Bone Exposed to Ionizing Radiation: Comparative Analysis of Two Segmentation Methods and Their Impact on Trabecular Measurements in an Animal Studypt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor-co1Pitorro, Tássio Edno Atanásio-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/1498837798159355pt_BR
dc.contributor.advisor1Soares, Priscilla Barbosa Ferreira-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/5032809676969673pt_BR
dc.contributor.referee1Soares, Priscilla Barbosa Ferreira-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/5032809676969673pt_BR
dc.contributor.referee2Lima, Lívia Bonjardim-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/2684147427433513pt_BR
dc.contributor.referee3Henriques, João César Guimarães-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/5357433616713642pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoThe study aimed to evaluate bone formation in surgical defects exposed to ionizing radiation (IR) and to compare two image segmentation methods: manual and standardized delimitation of the region-ofinterest (ROI). Bone defects were created in the tibias of Wistar rats using a 2.3 mm trephine. After seven days, the animals were exposed to IR (30 Gy single dose). Two weeks later, the animals were euthanized, and their tibias were scanned using X-ray microtomography. ROI definition was performed by a single operator using two methods: (a) interactive segmentation, where the woven bone was manually outlined within the bone defect region, and (b) a standardized, predefined rectangular ROI. Bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular number (Tb.N), bone surface (BS/BV), and fractal dimension (FD) were assessed for both segmentation methods. Significant differences were observed for BV/TV (p<0.001), Tb.N (p<0.001), and Tb.Sp (p<0.001), but not for Tb.Th (p=0.71), BS/BV (p=0.79), and FD (p=0.35). The manual method was approximately 3.5 times more timeconsuming than the predefined ROI method (446.2±49.5 vs 131.2±38.8 s, p<0.001). None of the evaluated parameters showed significant differences when the IR was considered. Within the limitations of this study, the finding indicate that IR does not interfere with the bone repair process when delivered postsurgery. While manual segmentation is more time consuming, it retrieves greater bone volume and reveals differences in trabecular structure, showing more trabeculae number and less trabeculae separation in irradiated bone.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseOdontologiapt_BR
dc.sizeorduration8pt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIApt_BR
dc.orcid.putcode183184537-
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