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https://repositorio.ufu.br/handle/123456789/44529| Document type: | Trabalho de Conclusão de Curso |
| Access type: | Acesso Aberto |
| Title: | Successful control of a large outbreak of colonization and infection by carbapenem-resistant klebsiella pneumoniae carbapenemase producer in ill neonates |
| Author: | Garcia, Laura Rodrigues |
| First Advisor: | Ribas, Rosineide Marques |
| First member of the Committee: | Silva, Helisângela de Almeida |
| Second member of the Committee: | Porto, Juliana Pena |
| Summary: | Failures in prevention and control measures in Neonatal Intensive Care Units (NICUs) facilitate the transmission of microorganisms like Klebsiella pneumoniae, causing outbreaks of colonization and invasive infections in neonates. Objective: We describe a large nosocomial outbreak of carbapenemase-producing K. pneumoniae in the neonatal unit of a university hospital in Brazil. Methods: Between July 2023 and February 2024, carbapenem-resistant K. pneumoniae (CRKP) samples were identified and tested for antimicrobial susceptibility using an automated identification and susceptibility testing system. The blaKPC, blaNDM, and blaCTXM-Gp-1 genes were investigated by polymerase chain reaction (PCR), and clonality was explored by pulsed-field gel electrophoresis (PFGE). Results: Thirty-six patients with CRKP were identified. 72.2% (26/36) were colonized, 33.3% (12/36) had infections, and 5.5% (2/36) had both. 37.5% (6/16) of the isolates harbored the blaKPC gene, 6.25% (1/16) blaNDM, and 12.5% (2/16) blaCTXM-Gp-1. Genotyping revealed five distinct PFGE profiles. Among the colonization samples, two clones were predominant: clone A with five isolates and clone C with six isolates. Conclusion: This study described a large nosocomial outbreak of carbapenemase-producing K. pneumoniae in the neonatal unit of a university hospital in Brazil. Although this outbreak was severe, spreading through the hands of healthcare professionals, it also highlights the potential of the infection control system to manage the outbreak. |
| Keywords: | Klebsiella pneumoniae Infectious Disease Outbreak Neonates Pulsed-Field Gel Electrophoresis blaKPC Infectious Disease Horizontal Transmission |
| Area (s) of CNPq: | CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::BIOLOGIA E FISIOLOGIA DOS MICROORGANISMOS CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADA CNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA MEDICA |
| Language: | eng |
| Country: | Brasil |
| Publisher: | Universidade Federal de Uberlândia |
| Quote: | GARCIA, Laura Rodrigues. Successful control of a large outbreak of colonization and infection by carbapenem-resistant klebsiella pneumoniae carbapenemase producer in ill neonates. 2024. 18 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2025. |
| URI: | https://repositorio.ufu.br/handle/123456789/44529 |
| Date of defense: | 26-Sep-2024 |
| Appears in Collections: | TCC - Ciências Biomédicas |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| SuccesSfulControlLarge.pdf | TCC | 1.12 MB | Adobe PDF |  View/Open |
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