1. Repositório Institucional - Universidade Federal de Uberlândia
  2. Instituto de Ciências Biomédicas (ICBIM)
  3. TCC - Ciências Biomédicas
Please use this identifier to cite or link to this item: https://repositorio.ufu.br/handle/123456789/44529
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dc.creatorGarcia, Laura Rodrigues-
dc.date.accessioned2025-01-08T17:39:43Z-
dc.date.available2025-01-08T17:39:43Z-
dc.date.issued2024-09-26-
dc.identifier.citationGARCIA, Laura Rodrigues. Successful control of a large outbreak of colonization and infection by carbapenem-resistant klebsiella pneumoniae carbapenemase producer in ill neonates. 2024. 18 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2025.pt_BR
dc.identifier.urihttps://repositorio.ufu.br/handle/123456789/44529-
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Uberlândiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectKlebsiella pneumoniaept_BR
dc.subjectInfectious Disease Outbreakpt_BR
dc.subjectNeonatespt_BR
dc.subjectPulsed-Field Gel Electrophoresispt_BR
dc.subjectblaKPCpt_BR
dc.subjectInfectious Disease Horizontal Transmissionpt_BR
dc.titleSuccessful control of a large outbreak of colonization and infection by carbapenem-resistant klebsiella pneumoniae carbapenemase producer in ill neonatespt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.contributor.advisor1Ribas, Rosineide Marques-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1574070947451743pt_BR
dc.contributor.referee1Silva, Helisângela de Almeida-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/2043644845839549pt_BR
dc.contributor.referee2Porto, Juliana Pena-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/3028857998253737pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/8240669313399328pt_BR
dc.description.degreenameTrabalho de Conclusão de Curso (Graduação)pt_BR
dc.description.resumoFailures in prevention and control measures in Neonatal Intensive Care Units (NICUs) facilitate the transmission of microorganisms like Klebsiella pneumoniae, causing outbreaks of colonization and invasive infections in neonates. Objective: We describe a large nosocomial outbreak of carbapenemase-producing K. pneumoniae in the neonatal unit of a university hospital in Brazil. Methods: Between July 2023 and February 2024, carbapenem-resistant K. pneumoniae (CRKP) samples were identified and tested for antimicrobial susceptibility using an automated identification and susceptibility testing system. The blaKPC, blaNDM, and blaCTXM-Gp-1 genes were investigated by polymerase chain reaction (PCR), and clonality was explored by pulsed-field gel electrophoresis (PFGE). Results: Thirty-six patients with CRKP were identified. 72.2% (26/36) were colonized, 33.3% (12/36) had infections, and 5.5% (2/36) had both. 37.5% (6/16) of the isolates harbored the blaKPC gene, 6.25% (1/16) blaNDM, and 12.5% (2/16) blaCTXM-Gp-1. Genotyping revealed five distinct PFGE profiles. Among the colonization samples, two clones were predominant: clone A with five isolates and clone C with six isolates. Conclusion: This study described a large nosocomial outbreak of carbapenemase-producing K. pneumoniae in the neonatal unit of a university hospital in Brazil. Although this outbreak was severe, spreading through the hands of healthcare professionals, it also highlights the potential of the infection control system to manage the outbreak.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.courseBiomedicinapt_BR
dc.sizeorduration18pt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::BIOLOGIA E FISIOLOGIA DOS MICROORGANISMOSpt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA APLICADApt_BR
dc.subject.cnpqCNPQ::CIENCIAS BIOLOGICAS::MICROBIOLOGIA::MICROBIOLOGIA MEDICApt_BR
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