Publicação: O uso de embriões como modelos experimentais
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CNPQ::CIENCIAS BIOLOGICAS
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Silva, Murilo Vieira da
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Animal embryos are vital tools in scientific research, providing insights into biological processes and disease mechanisms. This paper explores their historical and contemporary significance, emphasizing the shift towards refining in vitro systems as alternatives to animal experimentation. Across various species like rodents, rabbits, fish, amphibians, birds, and reptiles, different experimental models play crucial roles in understanding embryonic development and physiological processes. We conducted a data survey in relevant literature on the use of embryos in research and combined the data with the aim of presenting the importance of this model for scientific advancements and the ethical considerations and regulations surrounding embryo research, highlighting the importance of minimizing animal suffering while promoting scientific progress through the principles of replacement, reduction, and refinement. Mammalian embryos aid in studying embryogenesis and human conditions, while avian embryos are intermediate models for toxicity studies. Amphibian embryos offer insights into gene expression, reptile embryos provide understanding of genetic processes and thermoregulation, and fish embryos are valuable for genetics and ecotoxicity research. In conclusion, animal embryos facilitate transformative advancements in science and medicine, necessitating adherence to ethical principles and legal frameworks to uphold animal welfare and ensure responsible research conduct.
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Animal embryos, Biomedical research, 3Rs, Animal ethics, Alternative methods
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LOPES, Karina Pereira. O uso de embriões como modelos experimentais. 2024. 49 f. Trabalho de Conclusão de Curso (Graduação em Biomedicina) – Universidade Federal de Uberlândia, Uberlândia, 2024.
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